Constitutional POLE variants causing a phenotype reminiscent of constitutional mismatch repair deficiency - Sehested - 2022 - Human Mutation - Wiley Online Library
Genes | Free Full-Text | Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity
ESMO Virtual Congress 2020: High Activity of Nivolumab in Patients with Pathogenic Exonucleasic Domain POLE (edPOLE) Mutated Mismatch Repair Proficient Advanced Tumours
The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management | Familial Cancer
POLE proofreading defects: Contributions to mutagenesis and cancer. - Abstract - Europe PMC
POLE exonuclease mutations in endometrial cancer affect conserved... | Download Scientific Diagram
Role of POLE and POLD1 in familial cancer | Genetics in Medicine
Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus | Journal of Medical Genetics
Frontiers | Protumorigenic Role of Elevated Levels of DNA Polymerase Epsilon Predicts an Immune-Suppressive Microenvironment in Clear Cell Renal Cell Carcinoma
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer | bioRxiv
Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population | Scientific Reports
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study - The Lancet Gastroenterology & Hepatology
POLE/POLD1 mutation and tumor immunotherapy | Journal of Experimental & Clinical Cancer Research | Full Text
Frontiers | Analysis of Mutations and Dysregulated Pathways Unravels Carcinogenic Effect and Clinical Actionability of Mutational Processes
Mutations in the POLE exonuclease domain in ECs. (A) Mutations in the... | Download Scientific Diagram
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations | Scientific Reports
Pathogenic, somatic POLE mutations in precursors of endometrial and... | Download Scientific Diagram
Gencurix obtains approval for Droplex POLE Mutation Test
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer | PLOS Genetics
Cancers | Free Full-Text | Polymerase Epsilon-Associated Ultramutagenesis in Cancer
Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair | eLife
POLE/POLD1 mutation and tumor immunotherapy | Journal of Experimental & Clinical Cancer Research | Full Text
Cancers | Free Full-Text | Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy
Endometrial cancer with a POLE mutation progresses frequently through the type I pathway despite its high-grade endometrioid morphology: a cohort study at a single institution in Japan | SpringerLink
The structure of POLE and POLD1 demonstrating the position of key... | Download Scientific Diagram
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation | Modern Pathology
